Endocrine Abstracts

The local biological activity of the natriuretic peptides ANP, BNP and CNP is regulated by changes in the activity of their guanylyl cyclase (GC)-containing receptors GC-A and GC-B, by the so-called natriuretic peptide clearance receptor NPR-C and by membrane-bound ectoproteases. Activity of GCs is regulated by alterations in the extent of receptor phosphorylation. Dephosphorylation decreases natriuretic peptide-induced GC activity. This mechanism is used for desensitization i...